Methods for the Production of Sorangicins and Their Analogues

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes novel, efficient methods for synthesizing sorangicins and their analogues, which are potent antibiotics. The process involves assembling six specific chemical building blocks through a sequence of coupling and cyclization reactions to produce sorangicins or their analogues in high yield. This synthetic route allows for the creation of various analogues by varying the building blocks, facilitating the production of these complex natural products at scale without relying on fermentation or extraction from natural sources.

Use CasesContent extracted from patent full text and abstract with AI.

• Production of sorangicin antibiotics for clinical use against drug-resistant bacterial infections.
• Large-scale manufacturing of sorangicin analogues for pharmaceutical development and research.
• Development of new antibiotics with modified properties by tweaking building blocks.
• Use in antibiotic formulations for oral or parenteral administration.
• Potential for generating derivatives targeting specific bacterial pathogens (e.g., Acinetobacter baumannii, mycobacteria).

BenefitsContent extracted from patent full text and abstract with AI.

• Enables high-yield, scalable synthesis of complex macrolide antibiotics like sorangicins.
• Offers flexibility to synthesize a broad range of analogues by changing building blocks, facilitating drug development and optimization.
• Does not depend on biological fermentation or extraction processes, reducing variability and supply issues.
• Facilitates access to new or rare antibiotic compounds for testing against resistant bacteria.
• Simplifies the manufacturing process, potentially reducing costs and improving reproducibility for pharmaceutical production.

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Patent Abstract

The present invention describes a novel synthetic pathway for the production of sorangicins and their analogues according to a compound of formula (I), wherein the variables R1, R2, R3, R4, and R5 are defined in the description, providing the key building blocks according to formulae A, B, C, D, E, and F, which are described in the description, in coupling reactions and a final cyclisation to form a compound of formula (I). The compounds produced according to the present invention are useful as antibiotics.