Bioreactor System for Tissue Engineering

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This invention discloses an automated, closed bioreactor system specifically designed to efficiently create, cultivate, and test three-dimensional biological tissue constructs, such as those used for regenerative medicine, research, and food production. The bioreactor features a sterile cultivation chamber with support elements on which tissues are formed and maintained, minimizing the risk of contamination or mechanical damage. The system supports various sizes of tissue constructs and automation for continuous cultivation, perfusion, testing, and stimulation, all with minimal manual handling.

Use CasesContent extracted from patent full text and abstract with AI.

• Engineering human or animal tissues for transplantation or replacement therapies in medicine
• Creation of human-like tissue models for pharmaceutical drug development, screening, and toxicity testing
• Cosmetic industry studies for product safety and skin compatibility
• Production of artificial meat or cultured foods for food industry applications
• Developmental biology and disease modeling research using physiologically relevant tissue constructs
• Safety and functionality testing of biomaterials or new therapies in a laboratory environment

BenefitsContent extracted from patent full text and abstract with AI.

• Reduces risk of microbial contamination and mechanical damage by avoiding manual transfers and using a closed, sterile system
• Allows for continuous, automated cultivation and perfusion of tissues, improving reproducibility and ease of operation
• Accommodates a range of construct sizes from small, high-throughput research samples to clinically relevant sizes
• Facilitates direct measurement, testing, and stimulation of tissue constructs without disturbing their sterile environment
• Enables high-quality, physiologically relevant tissue constructs thanks to optimized growth conditions and optional stimulation modalities
• Supports modular and scalable production for both basic research and industrial applications, including food production

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Inventors & Applicants

Patent Abstract

The present invention relates to a novel bioreactor system for preparing an engineered three-dimensional biological tissue construct. The bioreactor system comprises a cultivation chamber that is designed to allow the formation, cultivation and the subsequent testing and/or stimulation of tissue constructs on one or more support elements with a minimum risk of microbial contamination or mechanical damage. The invention furthermore relates to a method for preparing an engineered tissue construct using the novel bioreactor system. The invention also relates to the use of the bioreactor system for preparing engineered biological tissue constructs, preferably tissue constructs which are suitable for being used in clinical tissue replacement and reconstructive therapy, drug development, drug screening, toxicity testing, cosmetic studies, safety testing, developmental studies, disease modeling, or food purposes.