Method for Determining the Therapeutic Effectiveness of Substances

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a method for determining the therapeutic effectiveness of biotechnologically produced proteins and/or peptides (such as therapeutic antibodies or similar biologic drugs) before they are used for patient treatment. The method involves labeling the therapeutic protein or peptide, applying it to a relevant patient-derived or reference sample (such as tissue, blood, or cells), and then analyzing how well it binds to target structures associated with the intended effect. The invention also includes a kit and a biochip that facilitate this testing, enabling personalized predictions of drug response and therapy monitoring without having to rely exclusively on genetic methods or time-consuming clinical trials.

Use CasesContent extracted from patent full text and abstract with AI.

• Predicting the effectiveness of biologic drugs (e.g., monoclonal antibodies) on individual patient samples before starting therapy.
• Personalizing dosing regimens for biologic drugs based on predicted binding and activity in patient samples.
• Monitoring patient response during ongoing biologic therapy to optimize treatment plans.
• Screening new biotechnologically produced therapeutic agents in vitro during drug development.
• Reducing animal testing and clinical trial duration by providing in vitro effectiveness data.
• Comparing the action of different biologic compounds on disease-affected versus healthy tissues.

BenefitsContent extracted from patent full text and abstract with AI.

• Allows personalized prediction of whether a specific biologic therapy will work for an individual patient, reducing ineffective treatments.
• Facilitates optimal dose selection and therapy monitoring, improving patient outcomes and minimizing side effects.
• Reduces the need for trial-and-error in drug prescribing, speeding up the choice of effective therapy.
• Decreases time and costs for pharmaceutical development by providing faster in vitro assessments.
• Minimizes unnecessary animal and human clinical testing, supporting ethical research approaches.
• Expands the range of diseases and conditions for which targeted biologic therapies can be evaluated efficiently.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a method for determining the therapeutic effectiveness of substances which contain, as active ingredient, at least one therapeutically effective protein and/or peptide produced using biotechnology. The invention also relates to a kit and a biochip for carrying out the method according to the invention.