Manufacturing Method for a Component for the Production of Astatine-211, Component and Use

Simple SummaryContent extracted with AI.

This invention covers a manufacturing method for producing a component containing a bismuth target used to generate Astatine-211 (At-211), a radioactive isotope of medical interest. The key process involves compressing bismuth powder in a press while applying heat, effectively sintering the powder into a solid, dense target. The resulting component is designed to be used at a cyclotron, where it is bombarded to produce At-211. The method offers a controlled and reproducible way to fabricate high-quality bismuth targets for radiopharmaceutical production.

Use CasesContent extracted with AI.

• Production of Astatine-211 at medical cyclotron facilities for use in targeted alpha-particle cancer therapy (TAT).
• Manufacturing of standardized bismuth targets for nuclear medicine research institutions studying At-211-based radiopharmaceuticals.
• Supply of ready-to-use sintered bismuth target components to hospitals or radiopharmacies operating on-site cyclotrons.
• Fabrication of bismuth targets for preclinical and clinical trials involving At-211-labeled antibodies or peptides for cancer treatment.

BenefitsContent extracted with AI.

• Hot-pressing bismuth powder produces a denser, more homogeneous target compared to casting or cold-pressing methods, improving At-211 yield consistency.
• The sintering process allows precise control over target geometry and density, enabling reproducible manufacturing of components.
• Using powder metallurgy avoids the high-temperature melting of bulk bismuth, reducing the risk of oxidation and material contamination.
• The method enables scalable and cost-effective production of bismuth targets suitable for routine clinical At-211 supply chains.
• Solid sintered targets offer improved thermal and mechanical stability under cyclotron beam bombardment compared to less consolidated forms.

Inventors & Applicants

Patent Abstract

The invention relates to a method for producing a component (6) with a target (7) formed from bismuth for the production of astatine-211, characterized in that powder (3) formed from bismuth is pressed in a press (1) with the supply of heat. The invention relates to a component that can be produced according to the method, and a use of the component on a cyclotron for the production of astatine-211.