Excelsus Structural Solutions
Excelsus Structural Solutions provides advanced synchrotron-based X-ray powder diffraction analytical services and consultancy for the pharmaceutical and related industries.
About
Excelsus Structural Solutions is a high-tech company originally founded in Brussels, Belgium in 2012 as a spin-off from the Paul Scherrer Institute (PSI) in Switzerland. In 2014, it established Excelsus Structural Solutions (Swiss) AG in Switzerland, currently located at Switzerland Innovation Park Innovaare in Villigen, Switzerland. The company enables industrial and academic customers, particularly in the pharmaceutical and (bio)pharmaceutical sectors, to access state-of-the-art synchrotron-based X-ray powder diffraction (S-XRPD) and related analytical tools. These services are designed to enhance drug development, formulation, manufacturing, intellectual property protection, and quality control. Excelsus offers routine and highly specialized measurements, consulting on patent litigation and regulatory compliance, and supports R&D projects requiring the highest detection sensitivity. The company is known for strict confidentiality, knowledge exchange with a global scientist network, and the development of novel measurement and data analysis methodologies for challenging applications including detection of impurities and phase traces down to 0.01% wt.
Products & Services
- Synchrotron X-ray Powder Diffraction (S-XRPD) analytical services
- Quantitative Phase Analysis (QPA) for trace detection in drugs
- Qualitative Phase Analysis
- Ab-initio crystal structure solutions
- Detection and quantification of minority phases down to 0.01% wt
- Pair Distribution Function (PDF) analysis
- Customized analytical R&D projects for clients
- Consulting for Intellectual Property (IP) protection and patent litigation
- Rapid access to synchrotron facilities for industrial R&D
- Sample preparation, experiment planning, and data analysis
- Detailed experimental and interpretive reports for clients
Use Cases & Case Studies
- Enhanced drug development and manufacturing through S-XRPD
- Detection of low-level impurities and minority phases in pharmaceuticals
- Patent protection via advanced analytical data
- Investigation and troubleshooting in commercial manufacturing
- Kinetic studies on pharmaceuticals at millisecond scales
- Case study: high-resolution structure of protein powders using S-XRPD published with Prof. Irene Margiolaki's group
- Case study: Small Angle X-Ray Scattering analysis for drug delivery systems
Partnerships & Collaborations
- Avant-garde Materials Simulation (AMS) - partnership to provide reliable crystal structures derived from high-resolution S-XRPD patterns, 2017
- NanoMEGAS (Belgium) & Bilde og Røntgenanalysesystemer AS (BoRAS, Norway) - Eurostars R&D project developing electron/X-ray combined analytical methods for nanocrystalline and amorphous pharmaceuticals, supported by EU funds
- Improved Pharma LLC (USA, Prof. Stephen Byrn) - collaboration on S-XRPD for both amorphous and crystalline pharmaceuticals and development of new procedures for PDF analysis
- Institute of Crystallography (CNR-IC), Bari, Italy - partnership to provide access to X-ray imaging facility for pharmaceutical nanocharacterization
Awards & Recognition
- Cited as a 'Mediator' company connecting industry with large research facilities by the EARIV (CAROTS EU-project)
- Co-organizer and sponsor of major international workshops and conferences in the field, such as PPXRD and SPS-XRPD
- Invited lectures and scientific advisory/organizing committee roles at major crystallography conferences
Contact Information
Certifications & Compliance
- Standard Operating Procedures (SOPs) for all services
- Services provided according to ICH Quality guidelines