Process and Means for the Cleavage of Esters, Amides and Thioesters of Formic Acid

Simple SummaryContent extracted from patent full text and abstract with AI.

The patent describes a method and means for splitting (cleaving) esters, amides, and thioesters of formic acid (formyl derivatives) using an enzyme called formate dehydrogenase. This process creates carbon dioxide and the related alcohol, amine, or thiol. The patent also covers a kit for removing formyl protecting groups which combines formate dehydrogenase and alcohol dehydrogenase enzymes, ideally immobilized on a shared carrier.

Use CasesContent extracted from patent full text and abstract with AI.

• Removing formyl protecting groups in organic synthesis, especially in pharmaceutical or fine chemical production.
• Biocatalytic processes to produce alcohols, amines, or thiols from their formyl derivatives.
• Development of enzymatic kits for academic or industrial laboratories to facilitate the selective cleavage of formyl groups in chemical compounds.
• Green chemistry applications where mild, enzymatic methods are preferred over harsh chemical processes for deprotection steps.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides a mild and selective enzymatic method for removing formyl protecting groups, which may better preserve sensitive molecules.
• Can be integrated into environmentally friendly or 'green' chemistry processes since it requires mild conditions and produces minimal harmful byproducts.
• Enzyme immobilization facilitates reuse of the catalyst and improves process efficiency.
• Useful for various industries, including pharmaceuticals, biotechnology, and academic research, where selective removal of protecting groups is essential.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

Cleavage of esters, amides or thioesters of formic acid, comprises converting ester, amide or thioester of formic acid to carbon dioxide and corresponding alcohol, amine or thiol by a formate dehydrogenase. An independent claim is also included for a kit for the cleavage of formyl protecting groups, comprising the formate dehydrogenase and alcohol dehydrogenase, preferably immobilized on a common carrier.