Process for the Enzymatic Synthesis of Aromatic Aldehydes or Ketones

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This invention describes a method for producing aromatic aldehydes or ketones using an enzymatic process. Specifically, it uses the enzyme styrene-oxide isomerase in an aqueous, cell-free system to convert mono- or bi-cyclic aryl epoxides into their corresponding aryl aldehydes or ketones. It also covers a process for extracting the enzyme from microorganisms, increasing the practicality of the method.

Use CasesContent extracted from patent full text and abstract with AI.

• Sustainable production of aromatic aldehydes or ketones for use in the fragrance and flavor industry
• Green chemistry synthesis routes in fine chemical production
• Manufacture of pharmaceutical intermediates
• Biocatalytic processes in industrial organic synthesis

BenefitsContent extracted from patent full text and abstract with AI.

• Environmentally friendly process compared to traditional chemical synthesis
• Potential for higher specificity and selectivity due to enzymatic catalysis
• Reduced need for harsh chemicals or extreme reaction conditions
• Improved yield and purity of target compounds
• Use of renewable biological resources (microorganisms) for enzyme production

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Patent Abstract

Enzymatic synthesis of aryl aldehyde (I) or aryl ketone (II) from mono- or bi-cyclic aryl epoxide, is claimed, where the enzymatic catalyzed synthesis takes place in a cell-free reaction mixture comprising styrene-oxide isomerase in an aqueous solution and a mono- or bi-cyclic aryl epoxide. An independent claim is included for extracting styrene-oxide isomerase from microorganism cell containing membrane-bound styrene-oxide containing isomerase comprising cultivating the microorganism cells in a culture medium comprising styrene, styrene oxide or phenylacetaldehyde; cell harvesting and performing a cell disruption; and extracting the constituents of the cell membrane from the disrupted microbial cells enriched with membrane-bound styrene-oxide isomerase.