Process for the Preparation of Amines

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses a process for the production of amines (specifically secondary and tertiary amines) via the reduction of carbamoyloxysilane derivatives using metal hydrides (such as lithium aluminum hydride or lithium borohydride) as reducing agents. The process employs safer starting materials, replacing traditionally hazardous ones like phosgene with carbon dioxide, and enables more selective methylation of primary and secondary amines to produce methylamine derivatives. The method can also generate hydridosilanes as valuable by-products.

Use CasesContent extracted from patent full text and abstract with AI.

• Manufacture of fine chemicals, pharmaceuticals, and agrochemicals that require methylamine derivatives as intermediates.
• Production of solvents, insecticides, pesticides, herbicides, detergents, and related chemicals using safer synthesis pathways.
• Preparation of aminosilane compounds for use in materials science or silicone chemistry.
• Synthesis of hydridosilanes for subsequent use in hydrosilylation reactions, polymer chemistry, or organic synthesis.
• Chemical processes where selective amine methylation is crucial, especially in the development of active pharmaceutical ingredients.

BenefitsContent extracted from patent full text and abstract with AI.

• Safer process by avoiding highly toxic or hazardous chemicals such as phosgene, dimethyl sulfate, formaldehyde, and methyl iodide.
• Greater selectivity in the methylation of primary versus secondary amines, minimizing overalkylation and unwanted byproducts.
• Utilizes CO2 as a C1 source, contributing to greener chemistry and potential CO2 utilization.
• Can be conducted under mild conditions (room temperature and pressure), improving safety, energy efficiency, and process simplicity.
• Offers a versatile synthetic route for both a broad range of methylamine derivatives and functionalized hydridosilanes, increasing chemical synthesis flexibility.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a process for producing an organic compound having a group of the formula IA or of the formula IB, wherein a compound that has a group of the general formula IIA or of the general formula IIB in which R1, R2 and R3 are independently selected from the group that consists of hydrogen, a substituted or unsubstituted C1-C12 alkyl group, a substituted or unsubstituted C1-C12 heteroalkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted heterocycloalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted alkylaryl group, a substituted or unsubstituted amino group, and a substituted or unsubstituted arylalkyl group; is reacted with a hydrogenation agent to the organic group that has a group of the formula IA or of the formula IB, and a hydridosilane.