PLOT Columns for Gas Chromatography and Methods and Apparatus for Their Manufacture

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This patent discloses a new type of gas chromatography column called a PLOT (Porous Layer Open Tubular) column, which features a fused silica capillary lined with a layer of metal-organic frameworks (MOF) crystallites grown directly on its inner surface. The patent also covers methods and apparatus for manufacturing these columns, involving specific surface modifications and coating processes to ensure a stable and functional MOF layer.

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• High-resolution gas chromatography for chemical analysis in laboratories
• Detection of trace gases in environmental monitoring
• Industrial process monitoring and control
• Quality control testing in pharmaceuticals and food industries
• Specialized gas separations for research and development

BenefitsContent extracted from patent full text and abstract with AI.

• Improved separation efficiency due to MOF's selective adsorption properties
• Enhanced sensitivity and specificity in gas analysis
• Stable and uniform MOF coating inside the capillary
• Customizable properties through choice of MOF and linker chemistry
• Potential for detecting a wider range of compounds compared to traditional columns

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Patent Abstract

Porous layer open tubular (PLOT) column comprises a fused silica capillary, whose inner surface has a grown up layer of metal-organic frameworks (MOF) crystallites. Independent claims are also included for: (1) preparing the PLOT column, comprising (a) modifying the inner surface of the gas chromatography fused silica capillary for generating functional groups on their surface, (b) coating the modified inner surface with the spacer molecules with a anchor group and a head group, (c) applying multiple alternating coating having a secondary building units (SBU) precursor solution containing compounds of formula (M wO x(OH) yA z), and a linker solution containing at least one ditopic organic compound, for growing of MOF crystallites and their compounds with the head groups of the spacer molecule, and (d) removing the residual solution; and (2) an apparatus for the production of PLOT columns with the MOF coating, comprising at least two controllable dosing units, a heating furnace for holding the capillary to be coated, inlet and outlet pipes for the capillary to be coated, and controllable valves in supply lines. w : 3-8; x : 1-4; y : 0-6; z : 2-12; M : metal; and A : at least one monotopic anion with at least one functional.