Miniaturized complex reactor system for analyzing and clarification of microbial metabolic processes of pharmaceutical products, comprises calorimetric reactor, two sensors arranged in the reactor, and inlet- and outlet channels

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This invention describes a small-scale, complex reactor system designed to analyze and clarify microbial metabolic processes, especially in pharmaceutical products. The system includes a calorimetric reactor with integrated sensors and temperature control, allowing precise monitoring and regulation of biochemical reactions in small sample volumes.

Use CasesContent extracted from patent full text and abstract with AI.

• Pharmaceutical quality control and research, by analyzing microbial metabolism in drug products.
• Development of new antibiotics and monitoring microbial resistance.
• Biotechnology process optimization, such as fermentation monitoring.
• Small-scale laboratory testing of microbial processes without the need for large reactors.
• Environmental monitoring using microbial assays.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables high-precision analysis of microbial metabolic processes in very small volumes (≤25 ml).
• Combination of thermal and sensory measurement allows comprehensive monitoring and control of reactions.
• Modular sensors provide flexibility for different measurement principles (potentiometric, amperometric, etc.).
• Miniaturized format reduces sample and reagent costs and speeds up testing.
• Thermostatic environment ensures stability and reliability of measurements.

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Patent Abstract

The miniaturized complex reactor system for analyzing and clarification of microbial metabolic processes of pharmaceutical products in small quantities, comprises calorimetric reactor (1) with a temperature measuring point (3) and a volume of = 25 ml, two modular integrated sensors (2a, 2b) arranged in the reactor, and inlet- and outlet channels for fluid media. The complex reactor system is formed by the combination of the universal thermal measuring principle with sensor for monitoring and regulation of process sequences. The miniaturized complex reactor system for analyzing and clarification of microbial metabolic processes of pharmaceutical products in small quantities, comprises calorimetric reactor (1) with a temperature measuring point (3) and a volume of = 25 ml, two modular integrated sensors (2a, 2b) arranged in the reactor, and inlet- and outlet channels for fluid media. The complex reactor system is formed by the combination of the universal thermal measuring principle with sensor for monitoring and regulating process sequences. The reactor container is placed in a thermostatic environment that realizes the temperature stability necessary to the detection of the measuring effect. The thermal signal detected by the temperature sensor characterizes the running process and the processes are given by the combination with the sensor possibilities for the analysis. Continuous and/or discontinuous processes are carried out through the possibility of the sensory detection of process parameters and of communication with the fluid system. The sensors alternatively work according to potentiometric-, amperometric-, impedimetric- and/or optical principles. The sensors exhibit a time constant thermal capacity, which is independent of the measuring signal.