Novel Albicidin Derivatives, Their Use and Synthesis

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses a new class of albicidin derivatives featuring amide bond isosteres, which are synthetic compounds inspired by the natural product albicidin. Albicidin, produced by certain bacteria, is known for its DNA gyrase inhibitory activity and potential as an antibiotic. The invention covers novel chemical variations of albicidin with the aim to enhance or modulate its antibacterial properties, as well as detailed synthetic routes for their preparation and evidence of their bioactivity against both Gram-positive and Gram-negative bacteria.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of new antibiotics to treat bacterial infections, especially those caused by antibiotic-resistant strains.
• Therapeutic use for infections caused by both Gram-positive and Gram-negative bacteria, including E. coli, Salmonella, Bacillus subtilis, and Micrococcus luteus.
• Use in pharmaceutical compositions for oral, intravenous, topical, and other forms of administration.
• Potential combination therapies with other antibiotics to improve efficacy and spectrum of bacterial coverage.
• Development of prodrugs and pharmaceutical salts for improved drug delivery and bioavailability.

BenefitsContent extracted from patent full text and abstract with AI.

• Offers novel antibiotic compounds effective against a broad range of both Gram-positive and Gram-negative bacteria.
• Some derivatives demonstrate potency comparable to or exceeding that of ciprofloxacin, a gold-standard antibiotic.
• Chemical modifications may overcome traditional mechanisms of antibiotic resistance seen in pathogens.
• Detailed synthetic methods provided, enabling reproducible manufacturing and potential for structural optimization.
• Flexible chemistry allows tuning of pharmacological and physicochemical profiles for specific therapeutic needs.
• Potential for improved safety, stability, and pharmacokinetics compared to existing antibiotics.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to an albidicin derivatives, in particular to amid bond isosteres compound according to general formula (1).