Albicidin Derivatives, Their Use and Synthesis

Simple SummaryContent extracted from patent full text and abstract with AI.

The invention relates to new derivatives of albicidin, a natural compound known for its potent antibiotic activity through inhibition of bacterial DNA gyrase. The patent discloses a wide class of structurally modified albicidin compounds with improved physicochemical and pharmacological properties, including better solubility and bioavailability, aiming to address bacterial resistance and enhance therapeutic effectiveness. These compounds can be synthesized by the described methods and formulated for various routes of pharmaceutical administration.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of infections caused by Gram-negative and Gram-positive bacteria, including resistant strains (e.g., E. coli, Salmonella, Klebsiella, Staphylococcus, Streptococcus)
• Antibiotic therapy for severe or multidrug-resistant bacterial infections, particularly those from the ESKAPE group of pathogens
• Development of new oral, intravenous, or topical antibiotic medications
• Use in combination therapies to overcome bacterial resistance mechanisms
• Potential use in veterinary medicine to treat bacterial infections in animals
• As research tools for studying DNA gyrase inhibition and antibiotic mechanisms in bacteria

BenefitsContent extracted from patent full text and abstract with AI.

• Expanded spectrum of antibacterial activity, including efficacy against both Gram-positive and Gram-negative bacteria
• Potential to overcome existing bacterial resistance, particularly due to novel structural features
• Improved pharmacokinetic properties such as solubility and bioavailability, leading to more effective drug delivery
• Selectable modifications for optimizing safety, tolerability, metabolic stability, and duration of action
• Flexible administration options including oral, injectable, and topical formulations
• Potential for reduced side effects and toxicity through selective targeting and prodrug approaches
• Opportunity for tailored antibiotic formulations suitable for different clinical needs

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a chemical compound according to general formula (1)