Circulation System

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention provides a self-contained circulation system capable of supporting the growth of capillaries and the creation of micro organoids or micro tissue sections in vitro. The system mimics the natural blood perfusion environment by using miniature channels, pumps, and biocompatible matrices, allowing for the growth of tissue structures with functional capillaries. It can be used to study drug effects, efficacy, side effects, biosafety, metabolite profiles, mechanisms of action, and tissue regeneration, all within a controlled, physiologically relevant environment, enabling advanced research and testing.

Use CasesContent extracted from patent full text and abstract with AI.

• Drug discovery and toxicity screening by monitoring the effects of compounds on organoids or micro tissues.
• Testing efficacy, side effects, and biosafety of pharmaceuticals in vitro using human-derived micro tissues.
• Modeling human organ function and disease for basic research and drug development.
• Investigating tissue regeneration processes and mechanisms.
• Studying metabolite formation and transport in organ-level models.
• Personalized medicine by testing patient-derived tissues/organoids for drug response.
• Cancer research utilizing tumor tissue in a controlled microenvironment.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables realistic in vitro modeling of human tissues with perfused capillaries, closely mimicking physiological conditions.
• Reduces reliance on animal testing by providing human-like tissue models in vitro.
• Supports co-culture of different tissue types within a single circulation system for comprehensive multi-organ interaction studies.
• Facilitates long-term tissue culture under controlled and monitored environments.
• Allows for high-content analysis with integrated sensors (such as for pH, oxygen, metabolites, etc.).
• Simplifies nutrient delivery and waste removal for tissue constructs, improving tissue viability over time.
• Permits detailed study of drug effects, including efficacy and side effects, in an organ-mimetic setting.
• Can utilize whole blood, plasma, or culture media, enhancing experimental flexibility.
• Offers modular expansion to include multiple tissue or organoid types, supporting complex studies like multi-organ interactions.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

This invention concerns a self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in said self-contained circulation system.