Neuronal switching circuit

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes a method to assemble a biological switching circuit that mimics the functional architecture of natural neuronal pathways outside the body (in vitro). The circuit includes a sender tissue or cell that produces a signal, an afferent pathway to a control center made of live neurons, an efferent pathway, and a responder tissue that reacts to neuronal signals. The assembled circuit can be monitored and is designed to be used for research, drug testing, as an implantable device, or as a biological replacement for technical (electronic) switching circuits.

Use CasesContent extracted from patent full text and abstract with AI.

• Modelling neuronal function and disease in laboratory research.
• Testing safety and efficacy of new drugs on human-like neuronal circuits before clinical trials (preclinical studies).
• Serving as a physiological model for different organs (e.g., gut, skin, retina, lung) in biomedical research.
• Creating implantable or transplantable neuronal circuits for regenerative medicine, such as restoring lost nerve function.
• Providing biological alternatives or supplements to electronic circuits in biosensor applications.
• Education and training in neurobiology using realistic, controlled biological models.
• Development of hybrid bio-electronic devices (neuroprosthetics), where biological circuits interface with electronic systems.

BenefitsContent extracted from patent full text and abstract with AI.

• Accurately mimics human neuronal pathways better than previous 2D or incomplete models, offering more physiologically relevant results.
• Enables real-time monitoring of neuronal signaling and responses, aiding precise experimentation and measurement.
• Supports 3D cell culture, allowing for complex, realistic cell arrangements and interactions.
• Allows coupling to technical (electronic) circuits, enabling the development of hybrid bio-electronic devices.
• Reduces reliance on animal models for early testing of drugs and treatments, aligning with ethical and regulatory trends.
• Facilitates research on neurodegenerative and other neurological diseases in a controlled environment using human-derived tissues.
• Can be constructed using different types of cells and tissues, making it adaptable for a variety of organs and experimental needs.

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Inventors & Applicants

Patent Abstract

The present invention relates to a method of assembling a biological switching circuit (1). In a preferred embodiment the invention comprises assembly of a tissue capable of producing a signal, an afferent signal transmitter, neurons which can act as a control centre (4), an efferent signal transmitter and a tissue which is able to respond to the neuronal signal. The invention also relates to a biological switching circuit (1) producible by the method of the invention and its use.