Polynucleotides Encoding for Polypeptides Involved in the Omphatolin Biosynthesis

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes polynucleotides (DNA/RNA sequences) encoding enzymes that are responsible for the biosynthesis of omphalotin compounds, particularly omphalotin A and its derivatives. The invention provides not only the sequences but also recombinant vectors and genetically modified host cells (such as yeast or fungi) that can be used to produce these bioactive peptides. Omphalotin A is a cyclic peptide with potent and selective activity against plant-pathogenic nematodes but is otherwise not phytotoxic or broadly active against other microbes. The patent also includes methods for efficiently producing and purifying omphalotin compounds via biotechnological means, bypassing complicated chemical synthesis.

Use CasesContent extracted from patent full text and abstract with AI.

• Production of omphalotin A for use as a biological plant protection agent (nematicide) in agriculture.
• Development of bio-based, environmentally friendly nematode control products for crop management.
• Biotechnological production of omphalotin derivatives for research into peptide-based bioactive compounds.
• Use in synthetic biology and metabolic engineering to create new antimicrobial or nematicidal agents.
• Serving as a platform for peptide drug development and discovery by modifying the biosynthetic pathway.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides a scalable and efficient biosynthetic route to produce omphalotin compounds compared to complex chemical synthesis.
• Enables environmentally friendly and selective control of plant-parasitic nematodes with minimal impact on non-target organisms.
• Facilitates the engineering of novel derivatives by modifying the encoded enzymes or polynucleotides, supporting discovery and optimization of new bioactive peptides.
• Allows expression in safe, well-characterized host organisms such as yeast or fungi, increasing feasibility for large-scale production.
• Potentially reduces agricultural reliance on chemical nematicides, offering a biological and less harmful alternative.

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Patent Abstract

The present invention refers to polynucleotides encoding for polypeptides involved in the omphatolin biosynthesis, the corresponding polypeptides, a vector comprising said polynucleotiedes and host cells comprising said vector.