TissUse
TissUse is a Berlin-based biotechnology company specializing in organ-on-a-chip (Multi-Organ-Chip) technologies for preclinical testing using human tissues.
About
TissUse is a biotechnology company based in Berlin, Germany, pioneering the development of sophisticated organ-on-a-chip technologies known as the Multi-Organ-Chip platform. This technology closely simulates the physiological activity of multiple human organs in a miniaturized context, enabling unparalleled preclinical systemic insight using human tissues. The platform provides an innovative approach to predict toxicity, ADME profiles, and efficacy in vitro, significantly reducing and replacing the need for animal testing and streamlining human clinical trials. Applications include drug development, chemical and cosmetic safety assessment, food and nutrition, and consumer products. TissUse's solutions have been widely adopted since 2012, and the company also actively collaborates on research advancing personalized precision medicine and organ/tissue repair.
Products & Services
- HUMIMIC Multi-Organ-Chip platform (devices and chips)
- HUMIMIC Starter (control unit)
- HUMIMIC AutoLab (automated chip lab)
- HUMIMIC AutoPlant (expandable automation for complex studies, in development)
- HUMIMIC ActSense (electro-physiological applications)
- HUMIMIC Chips (Chip2, Chip3, Chip3plus, Chip4, ChipXX/XY)
- Custom chip design services
- Safety and efficacy evaluation services for drugs, cosmetics, and chemicals
- Pre-clinical human disease modeling services
- Accessories (HeatSupport, iPSCs, etc.)
- Smart Hair Transplant (SHT) technology (licensed in Japan)
Use Cases & Case Studies
- Prediction of drug-induced liver injury (DILI) in pharmaceutical development
- ADME profiling and PBPK modeling
- Repeated dose multi-drug safety testing
- Personalized precision medicine (patient-on-a-chip)
- Modeling diabetes (pancreas-liver cross-talk)
- Cosmetic and chemical product safety assessment
- Systemic toxicity and immune reactivity studies
- Disease modeling (e.g., tuberculosis, Alzheimer’s disease)
- Aerosol toxicity and exposure studies via respiratory tract models
Partnerships & Collaborations
- AstraZeneca (collaboration in diabetes-on-a-chip and drug development)
- Roche (collaboration for hematopoietic toxicity and PK model development)
- Bayer (collaboration for liver-endocrine assay using Multi-Organ-Chip)
- Bill & Melinda Gates Foundation (funding for tuberculosis vaccine and drug testing project)
- ProBioGen AG (licensed Human Artificial Lymph Node Model integration)
- J. Hewitt (Smart Hair Transplant license in Japan)
- Philip Morris International (InHALES test platform for aerosol exposure)
- UCB, Orion Corporation, Sanofi, Servier, AstraZeneca, Boehringer Ingelheim (Liver Ring Trial collaboration)
- National Institutes for Food and Drug Control (NIFDC), China (regulatory application and training on Multi-Organ-Chip)
- Consortium HiPSTAR (Alzheimer’s research)
Awards & Recognition
- ISO 9001:2015 Certified Quality Management System
- ALTEX Award 2017
- Stifterverband's 'Innovative Through Research' seal (2020)
Contact Information
Certifications & Compliance
- ISO 9001:2015