Sample Carrier with a Reference Structure and Method for Producing a Sample Carrier with a Reference Structure

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This patent describes a method for manufacturing a plastic sample carrier (such as a microscope slide or multiwell plate) with a reference structure, like a grid or lines, created using a laser. Unlike traditional continuous lines, the reference structure here consists of multiple interrupted (dotted or dashed) lines. This approach significantly reduces the occurrence of surface contamination caused by the laser process, enhancing the quality of sample carriers for high-resolution microscopy and related applications.

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• High-resolution microscopy (fluorescence microscopy, confocal microscopy, transmitted light microscopy) where precise sample localization and minimal contamination are critical.
• Cell culture experiments requiring precise positioning and documentation of biological samples.
• Chemical or medical analysis in microfluidic devices where visual reference markers improve measurement accuracy.
• Manufacture of multiwell plates, Petri dishes, and other carriers needing integrated reference structures for automated imaging or analysis.
• Quality control environments where sample tracking and minimal particulate contamination are vital.

BenefitsContent extracted from patent full text and abstract with AI.

• Reduces surface contamination from laser processing, improving sample integrity and image quality in microscopy.
• Enables reliable and reproducible positioning and localization of samples on the carrier.
• Facilitates clear and permanent reference markers (such as grids or labels) that do not interfere with the optical properties of the carrier.
• Compatible with transparent plastics suitable for high-resolution imaging, including those with low autofluorescence.
• Flexible design—reference structures can be on or just below the surface, tailored for different microscopy techniques.
• Allows for mass production using plastics and modern laser technology, keeping costs reasonable while maintaining high cleanliness.

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Patent Abstract

Die Erfindung betrifft ein Verfahren zum Herstellen eines Probenträgers aus Kunststoff, umfassend die Schritte Bereitstellen eines Kunststoffkörpers, und Ausbilden einer Referenzstruktur im oder auf dem Kunststoffkörper, wobei das Ausbilden der Referenzstruktur ein Erzeugen wenigs-tens einer mehrfach unterbrochenen Linie mit Hilfe eines Lasers umfasst.