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Synendos Therapeutics AG

Synendos Therapeutics AG is a clinical-stage biotech company developing first-in-class endocannabinoid modulators for the treatment of neuropsychiatric and central nervous system (CNS) disorders.

BiotechnologyPharmaceuticalsLife SciencesNeuroscienceCentral Nervous SystemDrug DevelopmentCentral Nervous System Disorder Treatments
Founded: 2019

About

Synendos Therapeutics AG is a Swiss clinical-stage neuroscience company focused on developing innovative and potentially breakthrough therapies for neuropsychiatric and CNS disorders. Utilizing over a decade of research from the University of Bern, the company develops first-in-class selective endocannabinoid reuptake inhibitors (SERIs), targeting a novel mechanism in the endocannabinoid system (ECS) to restore natural brain function. The lead candidate, SYT-510, is aimed at treating diseases with high unmet medical need such as post-traumatic stress disorder (PTSD). Synendos' approach is supported by strong preclinical and clinical evidence, a robust patent portfolio, and significant grant and venture capital funding.

Products & Services

  • SYT-510 (lead drug candidate, selective endocannabinoid reuptake inhibitor for CNS disorders)
  • Development of second-generation SERIs (Selective Endocannabinoid Reuptake Inhibitors)
  • Research and development of drugs for neuropsychiatric and CNS disorders

Use Cases & Case Studies

  • Restoring endocannabinoid balance in CNS disorders such as PTSD, anxiety and mood-related disorders
  • Novel oral therapeutics with improved safety profile for patients with stress and mood-related CNS diseases

Partnerships & Collaborations

  • University of Bern (spin-out origin, ongoing access to ECS expertise)
  • BaseLaunch (venture accelerator and incubator support)
  • NCCR TransCure (collaboration in drug transporter research)
  • Collaboration with various CROs for medicinal chemistry development

Awards & Recognition

  • EMA Clinical Trial Authorisation for SYT-510 (2024)
  • Swiss Economic Award 2025 finalist (Deeptech / Life Sciences)
  • Bio-Neuroscience Award for 'Best Pitch' (2025)
  • Top 100 Swiss Startups (2021, 2022)
  • Top 100 Swiss Startup Public Voting Award 2021 (Biotech)
  • Innosuisse Certificate
  • Venture Leaders Life Science 2019
  • Venture Kick Stage III winner (2019)
  • BaseLaunch Phases I and II awardee
  • >>venture>> competition healthcare finalist

Contact Information

Certifications & Compliance

  • Innosuisse Certificate
  • EMA Clinical Trial Authorisation