Device and Method for Photometric Mass Measurement

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This invention describes a device and method for measuring the mass of very small objects, like individual biomolecules or viruses, using photometric techniques. The system utilizes at least one laser source that emits 'squeezed light'—a special quantum state of light with reduced photon noise. By directing this laser at the target and detecting the light scattered from the object, the device can determine mass without the need for molecular labels, offering improved signal-to-noise ratios and higher sensitivity than conventional techniques.

Use CasesContent extracted from patent full text and abstract with AI.

• Label-free detection and mass measurement of proteins, DNA, and other biomolecules in biological and medical research.
• Sensitive detection and analysis of viruses in virology and diagnostics.
• Quality control for pharmaceutical research and bio-manufacturing by measuring particle masses in solutions.
• Single-molecule studies and biophysics experiments that require precise, real-time mass analysis without labeling.
• Environmental monitoring where detection of tiny particles or pathogens is required.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables highly sensitive, label-free mass measurements, reducing the risk of sample alteration or damage.
• Improves signal-to-noise performance by employing squeezed light, allowing detection of weaker signals than previously possible.
• Reduces measurement time and avoids sample degradation due to lower required laser intensity and shorter exposure.
• Suitable for analyzing very small particles—including single biomolecules and viruses—that are difficult to measure with standard methods.
• The setup can be adapted for either transmitted or reflected light, providing flexibility for different experimental requirements.

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Patent Abstract

A device for photometric mass measurement, which has at least one laser source and an optical measuring unit. At least one laser source is directed onto the object to be examined, in particular individual biomolecules or viruses, and the optical measuring unit detects light scattered on the object to the examined, the laser beam comprising squeezed light.