New disubstituted heteroaryl compound useful for treating a disease consisting of viral diseases, proliferative diseases, neurodegenerative diseases, diabetes, malaria, and HIV infection

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This invention introduces a new class of chemical compounds known as disubstituted heteroaryl compounds, which can be used as medicines to treat a wide range of diseases, including viral infections, cancers (proliferative diseases), neurodegenerative conditions, diabetes, malaria, and HIV. These compounds work by inhibiting an enzyme called deoxyhypusine synthase, which plays a role in cell growth and other biological processes.

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• Treating viral diseases in humans, such as influenza or hepatitis.
• Serving as a therapy for various types of cancer (cytostatic or anti-proliferative agent).
• Protecting nerves and nerve cells in neurodegenerative diseases like Alzheimer's or Parkinson's disease.
• Managing blood sugar levels in patients with diabetes.
• Acting as a treatment for malaria.
• Providing antiviral therapy for HIV-infected individuals.
• Developing anti-inflammatory drugs for autoimmune or systemic inflammatory conditions.
• Enhancing cognitive function or memory (nootropic use).
• Using as plant protectants against viruses in agricultural settings.

BenefitsContent extracted from patent full text and abstract with AI.

• Potential to treat a wide variety of diseases with a single compound class, increasing versatility.
• Inhibits deoxyhypusine synthase, offering a novel therapeutic mechanism compared to existing drugs.
• May provide options for patients who are resistant to current therapies in cancer, HIV, and other diseases.
• Ability to develop derivatives (salts, solvates, prodrugs) for improved drug delivery and efficacy.
• Possibility of combining antiviral, antidiabetic, neuroprotective, and antiproliferative effects in single treatment regimens.
• Potential for reduced side effects by targeting a specific enzyme pathway.
• Broad applicability across medicine and agriculture (plant protection).

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

Disubstituted heteroaryl compound (I) is new. Disubstituted heteroaryl compound of formula (I) and their salt, solvate or prodrug is new. A, B : -C(=X)-NR3aR3b, -NR5-C (=X)-NR3aR3b (both preferred) or -NR3aR3b; Q : disubstituted aryl or heteroaryl (which is optionally substituted by substituents R10); R1a, R1b, R2a, R2b : H, halo, alkyl, cycloalkyl, haloalkyl, CN, OH, alkoxy, or haloalkoxy; R3a, R3b : alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl (all optionally substituted by one or more moieties consisting of H, halo, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, CN, OH, alkoxy, or haloalkoxy) or H; R4, R5 : H, alkyl or cycloalkyl; R10 : halo, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, CN, OH, alkoxy, haloalkoxy or NR3aR3b (all optionally substituted by one or more moieties consisting of halo, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, CN, OH, alkoxy, haloalkoxy or NR3aR3b); X : O, S, or NR4; and m, n : 1-5. [Image] ACTIVITY : Plant Protectant; Virucide; Cytostatic; Neuroprotective; Antidiabetic; Antimalarial; Anti-HIV; Antiinflammatory; Nootropic. MECHANISM OF ACTION : Deoxyhypusine synthase inhibitor.