Nucleic Acid Coding for Plant Adenosine Nucleosidases

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This patent discloses isolated or synthetic nucleic acids coding for plant adenosine nucleosidases (enzymes that break down adenosine into adenine and ribose). The invention includes recombinant DNA constructs, vectors, transgenic plants and cells expressing these nucleic acids, and methods to modify plant metabolism by introducing these genes. It also covers the use of these plant enzymes and their encoding nucleic acids for various applications, such as producing plants with altered purine metabolism, food and beverage production with reduced purine content, and as molecular markers or tools in plant biotechnology.

Use CasesContent extracted from patent full text and abstract with AI.

• Engineering crop plants (such as rice, tea, or coffee) to modify their purine, alkaloid, or cytokinin content for improved yield or altered composition.
• Producing dietary foods and beverages, such as beer, with a reduced purine content to benefit individuals prone to gout or related health issues.
• Using the nucleic acid sequences as molecular tools, such as positive or negative selection markers, in plant transformation and genetic engineering processes.
• Designing new plant varieties with specific methylation-dependent properties, influencing factors like caffeine or theobromine production (important for coffee and tea plants).
• Developing novel antitumor therapies by incorporating these plant enzymes into targeted gene therapy systems.
• Creating biocatalytic processes for biotechnology or pharmaceutical applications, utilizing the specific enzyme activities.
• Screening for or isolating other plant adenosine nucleosidase genes using the disclosed nucleic acid probes.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables precise metabolic engineering of plants to increase or decrease specific metabolites (such as caffeine, theobromine, or cytokinins), influencing plant growth, development, and product value.
• Facilitates the production of foods and beverages with lower purine levels, addressing health concerns for certain populations.
• Provides molecular tools and markers useful for advanced plant breeding, genetic modification, and selection systems.
• Reduces reliance on microbial enzymes for food processing by supplying plant-derived alternatives, which may be more acceptable in certain markets.
• Supports the development of tailored gene therapies or selection systems outside of plant biology, potentially in animal or human health.
• Allows for the discovery and creation of new biocatalysts by enabling the modification or comparison of adenosine nucleosidase sequences from various plants.
• Promotes sustainable agriculture by enabling the custom design of crops tailored to specific metabolic profiles or nutritional needs.

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Patent Abstract

The invention relates to a nucleic acid coding for plant adenosine nucleosidases, this nucleic acid comprising recombinant DNA, chimerical DNA, DNA constructs, expression vectors, transgenic host cells, and plants, and adenosine nucleosidases, and to uses of the nucleic acid and of adenosine nucleosidases. The invention further also relates to a method for the production of plants having a modified metabolism, and transgenic plants. The present invention provides, for example, an isolated or synthesized nucleic acid coding for plant adenosine nucleosidases, and plant adenosine nucleosidases.