Use of Novel Substances for Pathogen Defence and Growth Promotion in Cultivated Plants

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This patent describes the use of novel substances that inhibit the activation of the eukaryotic initiation factor 5A (eIF-5A) to defend cultivated plants against pathogens, specifically phytopathogenic fungi, and to promote plant growth. The invention focuses in particular on inhibitors of the enzyme deoxyhypusine synthase (DHS), with examples such as CNI-1493 and GC7, for application on crops like wheat and maize. These substances, when applied to plants, can significantly suppress fungal infection and also increase crop yields.

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• Agriculture: Protecting cereal crops (wheat, maize, rye, barley, etc.) from pathogenic fungi such as Fusarium species to reduce crop diseases and contamination.
• Food safety: Reducing mycotoxin contamination (toxic substances produced by certain fungi) in food and animal feed, thereby improving food safety and reducing health risks for humans and animals.
• Crop yield enhancement: Promoting the growth and productivity of cultivated plants, resulting in higher yields for farmers.
• Greenhouse and field agriculture: Application of the inhibitors as plant protectants in both controlled-environment greenhouses and traditional outdoor farming.
• Organic or low-pesticide farming: Use as an alternative or supplement to conventional fungicides, potentially with lower toxicity.

BenefitsContent extracted from patent full text and abstract with AI.

• Effective control of a broad range of fungal pathogens, including those for which traditional fungicides are inadequate or unavailable.
• Reduction of mycotoxin contamination in crops and harvested products, leading to safer food and feed.
• Increased crop yield and quality due to both pathogen suppression and promotion of plant growth.
• Potentially lower environmental impact compared to conventional chemical fungicides if the substances are more targeted or have lower toxicity.
• Versatile application methods (such as spraying) and suitability for various types of cultivated crops.
• Can be used both preventively (to prevent infection) and curatively (to suppress an ongoing infection).

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Patent Abstract

The invention relates to the use of substances inhibiting the transformation of the eucaryotic initiation factor 5A (eIF-5A) from the inactive form thereof to the active form thereof, for controlling plant pathogens. The invention also relates to the use of said inhibitors for growth promotion in cultivated plants.