Measurement Cell for Saxs Measurements and for Dls Measurements

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention is a specialized measurement cell that allows for both Small Angle X-ray Scattering (SAXS) and Dynamic Light Scattering (DLS) measurements to be performed on a single, identical sample within the same compartment. By integrating light sources, detectors, and optical pathways, it enables users to obtain complementary data—such as size, shape, and dispersity of particles or biological samples—quickly and efficiently, improving quality assessment and analysis, especially for biological and nanomaterial solutions.

Use CasesContent extracted from patent full text and abstract with AI.

• Quality assessment of biological samples, such as proteins, in research and pharmaceutical development
• Analysis of colloidal systems (e.g., nanoparticles, polymers, foods, emulsions) to determine particle size, aggregation, and structure
• High-throughput screening of samples in synchrotron SAXS beamlines or laboratory SAXS devices
• Inline monitoring and optimization of chemical and biophysical processes involving macromolecules
• Automated analysis of sample quality in biophysical characterization pipelines (e.g., for structural biology)
• Quality control in industrial processes involving nanomaterials or protein formulations

BenefitsContent extracted from patent full text and abstract with AI.

• Allows simultaneous or sequential SAXS and DLS measurements on the exact same sample, reducing errors due to sample variation
• Saves time and sample material by combining two analytical methods in one device
• Improves data reliability and quality assessment by enabling complementary interpretation of particle size (hydration radius) and shape (gyration radius)
• Automates sample handling, data collection, and analysis for high-throughput applications
• Reduces risk of sample degradation between measurements (especially important for sensitive biological materials)
• Supports both research and industrial environments with flexible, modular, and vacuum-compatible design
• Facilitates automated flagging and quality control by integrating with software pipelines

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Patent Abstract

The present invention relates to a measurement cell which facilitates a small angle X-ray scattering measurement and facilitates dynamic light scattering measurements within the identical sample compartment of a sample holder. Light transportation means which are arranged and configured for transporting light of the light source towards the sample in the sample compartment and/or for transporting light scattered from the sample towards the detector are comprised. For example, a first and a second window which are optically transparent for the DLS light and the scattered light are presented. The first and second windows are provided at a sample holder which is specifically designed as a SAXS sample holder. Furthermore, a method of solution scattering for quality assessment of a sample is presented.