Mass spectrometer detector using optically active membrane

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a novel detector for mass spectrometry that uses a thin, optically active membrane to convert the kinetic energy of incoming molecules into photons (light). These photons are then detected by a photosensor, providing an electrical signal that corresponds to the arrival and characteristics of the molecules. The design leverages quantum-well structures within semiconductor membranes to enhance sensitivity, particularly for detecting large biomolecules such as proteins.

Use CasesContent extracted from patent full text and abstract with AI.

• Mass spectrometers for biochemical research, allowing precise detection and analysis of large ions (such as proteins, peptides, and oligonucleotides)
• Proteomics and genomics labs for detailed molecular analysis of biological samples
• Pharmaceutical and drug development, especially for characterizing complex biomolecules
• Clinical diagnostics based on mass spectrometry of biomarkers
• Forensic labs requiring sensitive detection of trace biological samples
• Environmental monitoring for sensitive detection of pollutants or complex organic molecules

BenefitsContent extracted from patent full text and abstract with AI.

• Higher sensitivity, especially for large molecules that are difficult to detect using traditional charge-based detectors
• Allows room temperature operation, simplifying instrument design and maintenance
• Improved signal-to-noise ratio by using photon detection, enhancing measurement accuracy
• Potential for precise spatial discrimination, allowing for high-resolution analysis of where molecules impact the detector
• Single-molecule detection capability, enabling more sensitive and quantitative experiments
• Fabrication leverages established semiconductor and photonic manufacturing processes, potentially lowering costs and improving scalability
• Tunable sensitivity using electrical or optical bias, allowing adaptation to different experiment needs

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Patent Abstract

A detector suitable for mass spectroscopy uses a thin membrane that converts the kinetic energy of impinging molecules into corresponding photons, the latter detected with a suitable photosensor. The arrival of molecules at the membrane is detected by detection of the corresponding photons.