Combination of nitroprusside and a sulfide salt as an HNO-releasing therapeutic for the treatment or prevention of cardiovascular diseases

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent introduces a therapeutic approach for treating or preventing cardiovascular diseases by combining a nitroprusside salt (such as sodium nitroprusside) with a sulfide salt (such as sodium sulfide). The main innovation is that the combination safely releases nitroxyl (HNO), a potent vasodilator, while simultaneously converting the toxic cyanide byproduct of nitroprusside into harmless thiocyanate. This reduces the risk of cyanide toxicity, enabling higher or safer dosing in cardiovascular treatments like heart failure, heart attack, and hypertension.

Use CasesContent extracted from patent full text and abstract with AI.

• Acute treatment of hypertensive crises to quickly lower blood pressure.
• Management of acute or chronic heart failure in hospitalized patients.
• Treatment of heart attacks (myocardial infarction) to improve cardiac function.
• Adjunct therapy in hypertension, especially where rapid blood pressure control is needed.
• Therapy for other cardiovascular conditions such as angina pectoris, pulmonary hypertension, and coronary artery disease.
• Potential use as a vasodilator in wound healing or treatment of trauma, such as anal fissure.
• Veterinary use in treating cardiovascular disorders in animals.

BenefitsContent extracted from patent full text and abstract with AI.

• Safely neutralizes the cyanide toxicity associated with nitroprusside therapy by converting it to thiocyanate.
• Generates HNO, a potent vasodilator, which also has positive effects on cardiac function and does not induce nitrate-tolerance.
• Allows for higher or prolonged dosing of nitroprusside without the risk of cyanide poisoning.
• Expands the therapeutic applicability of nitroprusside to a wider range of cardiovascular conditions.
• Provides both vasodilatory and positive inotropic effects, improving the ability to manage complex cases of heart failure or hypertensive emergency.
• Results in a potentially improved safety profile relative to standard nitroprusside therapy.
• Can be administered alone or in combination with other common cardiovascular drugs.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to the combination of a nitroprusside salt or a solvate thereof with a sulfide salt or a solvate thereof for use in the treatment or prevention of a cardiovascular disease/disorder, such as heart failure, heart attack or hypertension.