Mu Opioid Receptor Modulators

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes novel chemical compounds that modulate the activity of the mu opioid receptor (MOR), a key protein involved in pain perception. Unlike traditional opioid drugs, these compounds are designed to selectively activate specific signaling pathways within the receptor, aiming to maximize pain relief while minimizing dangerous side effects such as respiratory depression, constipation, and addiction. The invention includes both compositions and methods for using these compounds in pharmaceutical applications to treat pain, opioid overdose, addiction, and certain psychiatric disorders.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of safer pain management medications with reduced risk of addiction and respiratory side effects.
• Therapeutic treatment of acute and chronic pain in various medical scenarios, such as post-surgical recovery or cancer-related pain.
• Intervention in cases of opioid overdose to counteract dangerous symptoms without compromising safety.
• Treatment of opioid or other drug addiction by modulating dependence-related pathways.
• Addressing certain psychiatric disorders like depression and anxiety via modulation of mu opioid receptor activity.
• Research tools to study opioid receptor function and signaling separation.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides effective pain relief comparable to traditional opioids, but with a significantly lower risk of causing respiratory depression or constipation.
• Compounds have a substantially lower addiction potential than commonly used opioids like morphine, fentanyl, or heroin.
• New chemical structures introduce the possibility of unique pharmacological profiles and improved clinical outcomes.
• Selective signaling bias reduces harmful side effects associated with non-selective opioid receptor activation.
• Versatility in treating not only pain, but also opioid overdose, addiction, and some psychiatric disorders.
• Supports efforts to address the opioid crisis by offering safer alternatives and tools for pharmacological research.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.