Collagen Implant

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes a method for preparing highly pure collagen by treating collagen-containing tissues with a strong alkaline solution (pH >12), followed by cleaning with a chaotropic agent. The process is suitable for dense tissues like meniscus, cartilage, or tendons and aims to remove non-collagen impurities, antigens, pathogens, and other cellular components, resulting in a sterilized, biocompatible collagen implant that retains its natural three-dimensional structure. The purified collagen is intended for direct use as implants, especially in orthopedic and reconstructive surgeries, such as meniscus replacement.

Use CasesContent extracted from patent full text and abstract with AI.

• Orthopedic surgery, particularly for meniscus repair or replacement.
• Cartilage repair or regeneration in joints including the knee, spinal discs, or other load-bearing articulations.
• Use as a biocompatible scaffold for tissue engineering to grow new cartilage or other tissues.
• Creation of implants for reconstructive or regenerative medicine in trauma or sports injuries.
• Potential veterinary applications for animal orthopedic procedures.
• Development of cell-seeded implants for advanced tissue engineering research.

BenefitsContent extracted from patent full text and abstract with AI.

• Produces highly pure collagen with >99% purity, minimizing the risk of immune rejection and inflammatory responses.
• Removes pathogens (viruses, bacteria, prions), reducing infection risk for the implant recipient.
• Retains the native three-dimensional collagen scaffold, which supports cell colonization and tissue integration after implantation.
• Does not require complex enzymatic digestion or matrix disintegration/cross-linking, simplifying manufacturing and maintaining mechanical properties of the original tissue.
• Applicable to dense tissues where previous methods failed to achieve high purity without damaging structure.
• Potential for automated, scalable, and cost-effective production due to use of standard chemicals and processes.
• Sterility of the resulting implant is ensured through process steps, often making further sterilization unnecessary.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a highly pure collagen, its use as an implant and a method for its preparation, the method comprising subjecting a sample comprising collagen to at least one alkaline treatment step in an alkaline solution at a pH > 12 and at least one cleaning step with at least one chaotropic agent.