Formulation Comprising Bioactive Agents And Method Of Using Same

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes formulations and methods for creating bioactive microparticles containing bone morphogenetic protein-2 (BMP-2). These microparticles are designed to improve the stability, storage, and delivery of BMP-2 for use in medical applications, especially for bone and tissue regeneration. The microparticles can be provided as powders or suspensions and are made using processes that preserve BMP-2's bioactivity. They can also be associated with biodegradable carriers for sustained or targeted delivery.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment and enhancement of bone healing in fractures, such as tibial, spinal, or maxillofacial bones
• Support for dental repair, including periodontal disease and tooth regeneration
• Accelerated wound healing in burns, ulcers, and surgical incisions
• Regeneration of cartilage in joint injuries or degeneration
• Therapies for osteoporosis and related skeletal conditions
• Tissue engineering for reconstructive surgery or implants
• Veterinary applications in domestic animals and thoroughbred horses for orthopedic or trauma care

BenefitsContent extracted from patent full text and abstract with AI.

• Improved stability and storage of BMP-2 through microparticle formulation, reducing protein degradation
• Controlled release and targeted delivery to specific injury or defect sites
• Versatility in formulation: can be lyophilized (freeze-dried) or suspended in liquid for various delivery methods (e.g., injection, topical application, oral, or implant matrix)
• Retention of BMP-2 bioactivity after processing, ensuring therapeutic efficacy
• Potential for combination with other growth factors and bioactive agents, enhancing regenerative outcomes
• Use of biodegradable carriers allows safe, resorbable delivery within the body
• Customizable microparticle sizes and release profiles for different clinical needs and tissue targets

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

Disclosed are methods of making bioactive BMP-2 microparticles and methods of using the microparticles.