Freeze Dried Drug Nanosuspensions

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses stable, freeze-dried (lyophilized) drug nanosuspensions, particularly for poorly water-soluble drugs (such as rilpivirine). The formulation includes a steric stabilizer (often a solid at room temperature like poloxamer 338) and may also contain a cryoprotectant or lyoprotectant (such as polyvinylpyrrolidone or saccharides). After freeze-drying, the composition remains stable during long-term storage and can be quickly reconstituted to form a nanosuspension suitable for oral or parenteral administration, especially for long-acting injectable therapies.

Use CasesContent extracted from patent full text and abstract with AI.

• Long-acting injectable formulations for HIV therapy or prevention (especially with drugs like rilpivirine)
• Parenteral (intramuscular or subcutaneous) administration of poorly soluble drugs over extended periods
• Depot formulations enabling infrequent dosing (e.g., monthly or quarterly injections)
• Reducing pill burden for patients on chronic medication regimens
• Improved shelf-stable drug formulations suitable for environments with challenging logistics or limited refrigeration
• Reconstituted nanosuspensions for oral or injectable delivery of anti-infective, antifungal, antineoplastic or other poorly soluble drugs

BenefitsContent extracted from patent full text and abstract with AI.

• Enhanced long-term particle size stability, ensuring consistent drug delivery upon storage and reconstitution
• Enables sustained or depot drug release, reducing dosing frequency and improving patient adherence
• Applicable to a wide variety of poorly soluble drugs
• Reduces pill burden for patients, which can improve compliance and therapeutic outcomes
• Can be tailored for oral or injectable use, adding formulation flexibility
• Suited for environments where cold chain/storage stability is a concern, due to improved shelf life
• Improved ease of administration, local tolerance, and customizable dosing regimens

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a freeze-dried (also called lyophilized) drug nanosuspension. The present freeze-dried drug nanosuspension composition has an acceptable stability of the particle size distribution during storage, including long term storage.