Cell Nucleus-Entering Compositions

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes compositions and methods that use specially designed short protein fragments (polypeptides) that can enter the cell nucleus. These polypeptides, such as those with the sequences LKKTET, LKKTNT, or KSKLKK, are linked to therapeutic or diagnostic agents to help them effectively reach the cell nucleus where they can act.

Use CasesContent extracted from patent full text and abstract with AI.

• Delivering drugs directly to the cell nucleus to treat diseases like cancer
• Transporting DNA, RNA, or gene-editing components into cells for gene therapy
• Introducing nuclear-localized imaging or diagnostic markers for cell biology research
• Improving the efficacy of therapeutics that need to target nuclear pathways

BenefitsContent extracted from patent full text and abstract with AI.

• Enables targeted delivery of therapeutic or diagnostic agents to the cell nucleus
• Potentially increases effectiveness and reduces side effects of treatments
• Facilitates gene editing and advanced genetic therapies by improving nucleus entry
• Provides a versatile tool applicable to a variety of diseases and research areas

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET (SEQ ID NO: 1), amino acid sequence LKKTNT (SEQ ID NO: 2) or amino acid sequence KSKLKK (SEQ ID NO: 3), or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.