Load Bearing Bone Replacement Implants with Hierarchically Organized Architecture Derived from the Transformation of Plant Structures

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This patent discloses a bone substitute implant with a unique, hierarchically organized architecture derived from transformed plant structures (specifically certain types of wood). It consists of a porous core made of hydroxyapatite (HA) or a collagen-HA composite, surrounded by a mechanically strong shell made from HA or silicon carbide (SiC), also processed from wood with lower porosity. This design mimics the natural structure of bone, providing both mechanical strength and biocompatibility, and is primarily intended for the substitution and regeneration of load-bearing bones such as the femur, tibia, or humerus.

Use CasesContent extracted from patent full text and abstract with AI.

• Orthopedic implants for repairing or replacing load-bearing long bones (e.g., femur, tibia, humerus, radius, metatarsus).
• Bone tissue regeneration in trauma, tumor resection, or degenerative diseases affecting bone.
• Scaffolds for promoting bone growth in reconstructive surgery and orthopedic applications.
• Dental implants that require both mechanical strength and bioactivity.
• Implants for veterinary bone repair in animals.

BenefitsContent extracted from patent full text and abstract with AI.

• Hierarchically organized structure closely replicates natural bone, promoting better integration and function.
• Provides significant mechanical strength suitable for load-bearing applications, reducing the need for additional fixation techniques.
• Bioactive and bioresorbable, supporting bone regeneration and gradual replacement with natural bone tissue.
• Derived from natural plant structures, allowing for scalable, potentially cost-effective manufacturing.
• Enhanced vascularization and cell proliferation due to interconnected macro- and micro-porosity.
• Versatile, with customizable core and shell compositions to match different clinical needs and mechanical requirements.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibres and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.