Dry diagnostic reagent

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a novel dry diagnostic reagent for blood coagulation testing. The invention is a highly water-soluble, low-hygroscopicity compound created by mixing two or more organic calcium (Ca2+) salts at a molecular level, preventing crystallization and resulting in an amorphous solid. The reagent, which can be freeze-dried, dissolves quickly and delivers calcium ions needed for recalcifying blood in in-vitro coagulation assays without the drawbacks of traditional reagents like CaCl2, which is highly hygroscopic and unsuitable in dry form.

Use CasesContent extracted from patent full text and abstract with AI.

• In-vitro blood coagulation measurement in clinical laboratories (e.g., aPTT, PT, thromboelastometry, and thromboelastography tests).
• Point-of-care testing kits for rapid coagulation analysis in emergency and operating rooms.
• Blood testing devices used in critical care units where fast and consistent coagulation measurement is required.
• Diagnostic kits for medical research into blood coagulation disorders.
• Sample preparation for blood analysis in pharmaceutical research, especially in studies dealing with anticoagulants.

BenefitsContent extracted from patent full text and abstract with AI.

• Eliminates the handling and storage issues associated with hygroscopic calcium sources like CaCl2, since it absorbs minimal moisture from air.
• Ensures no dilution of blood samples or interference with coagulation assays, as the reagent is solid, ready-to-use, and does not introduce extra liquid.
• Rapidly dissolves and recalcifies blood samples, ensuring accurate and efficient coagulation measurement.
• Can be manufactured and stored in a stable, amorphous form that remains effective even in humid environments.
• Reduces user error by allowing direct addition of blood to the dry reagent, minimizing pipetting and preparation steps.
• Compatible with existing coagulation testing protocols, showing no negative impact on test results compared to standard reagents.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a dry diagnostic reagent comprising at least a highly water soluble and low hygroscopic compound resulting from a mixture of two or more organic Ca 2+ salts that interact on the molecular level in a manner that at least partially prevents crystallization of the resulting compound and the use of such a reagent in an in vitro method for measuring the coagulation of a blood sample.