Method for Measuring Sodium Content in Tissue by Means of Magnetic Resonance Technique and Magnetic Resonance System

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention provides a novel method and apparatus for measuring the sodium content in human tissue using magnetic resonance (MR) technology. It determines the amount of sodium in tissue by first measuring the sodium signal from both tissue and blood, then calculating and subtracting the sodium signal specifically coming from blood vessels, which results in a more accurate measurement of sodium content within the tissue itself.

Use CasesContent extracted from patent full text and abstract with AI.

• Medical diagnostics to assess tissue health by measuring sodium levels.
• Monitoring diseases where sodium balance is important, such as kidney disease or heart failure.
• Research in neuroscience to study brain tissue integrity.
• Sports science to evaluate muscle tissue hydration and electrolyte balance.
• Preclinical drug studies to assess treatment effects on tissue sodium content.

BenefitsContent extracted from patent full text and abstract with AI.

• More accurate and reliable measurement of tissue sodium content by compensating for blood sodium contribution.
• Non-invasive monitoring using MR technology, avoiding the need for biopsies.
• Enhanced diagnostic capabilities for conditions where tissue sodium is a biomarker.
• Improved ability to monitor disease progression and treatment efficacy.
• Potentially broader application in both clinical and research settings.

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Patent Abstract

In a magnetic resonance method and apparatus to measure a sodium content in tissue in a first slice, a determination of a blood volume in blood vessels in the first slice is made, and an MR acquisition sequence to acquire MR data of a sodium-23 magnetization from the first slice is implemented. A signal proportion of the MR data that originates from the sodium-23 magnetization in blood vessels is calculated based on the determined blood volume in tissue. This signal proportion is subtracted from a total signal of the MR data to obtain a corrected signal that is proportional to the sodium content in tissue. The sodium content in tissue is calculated from the corrected signal.