Process for the Synthesis of Aminobiphenylene

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent discloses a new process for synthesizing 2-aminobiphenylene and its derivatives. The method involves reacting a benzene diazonium salt with an aniline compound under basic conditions (high pH), enabling the selective formation of various aminobiphenyl derivatives. The resulting aminobiphenyls can then be further modified, such as by acylation, to produce compounds useful as pharmaceuticals and agrochemicals.

Use CasesContent extracted from patent full text and abstract with AI.

• Synthesis of intermediates for pharmaceutical compounds, like kinase inhibitors or γ-secretase inhibitors.
• Manufacturing active ingredients for agricultural chemicals, such as fungicides or herbicides (e.g., Boscalid).
• Production of biaryl amines for advanced material science applications, including polymers and electronic materials.
• Research and development of new functionalized aromatic amines for specialty chemicals.

BenefitsContent extracted from patent full text and abstract with AI.

• Cost-efficient synthesis due to affordable and accessible starting materials (anilines and diazonium salts), avoiding costly metals like palladium.
• Environmentally friendlier by not relying on heavy metal catalysts or toxic reagents, compared to traditional cross-coupling methods.
• Flexible and broad applicability for introducing various functional groups via the wide substrate range of anilines and diazonium salts.
• Potential for higher selectivity and yield for certain biaryl amines that are challenging or inefficient via conventional routes.
• Simplified process conditions (aqueous/basic) and suitability for scale-up in industrial production.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.