Producing enantiomerically enriched nitroalkane compounds, comprises reacting prochiral nitroalkene compounds in the presence of a biocatalyst in highly enantioselective manner

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This patent describes a method to produce enantiomerically enriched (chiral) nitroalkane compounds by reacting prochiral nitroalkene compounds with a biocatalyst. The process is highly selective and results in products with an enantiomeric excess greater than 90%.

Use CasesContent extracted from patent full text and abstract with AI.

• Manufacturing of chiral intermediates for pharmaceutical synthesis
• Production of agrochemicals where chirality is essential for activity or safety
• Creation of fine chemicals for use in fragrances or flavors requiring specific enantiomers
• Research in organic and medicinal chemistry requiring pure enantiomers

BenefitsContent extracted from patent full text and abstract with AI.

• Achieves high enantiomeric purity (over 90%) in the target compounds
• Utilizes biocatalysts, which are safer and greener compared to traditional chemical catalysts
• Enables the efficient and scalable synthesis of valuable chiral building blocks
• Potentially reduces production costs by simplifying chiral separation processes

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Patent Abstract

Producing enantiomerically enriched nitroalkane compounds (I) or (II), comprises reacting prochiral nitroalkene compounds (III) in the presence of a biocatalyst in highly enantioselective manner, where enantiomeric excesses of desired product of (I) or (II) are greater than 90%. Producing enantiomerically enriched nitroalkane compounds of formula (I) or (II), comprises reacting prochiral nitroalkene compounds of formula (III) in the presence of a biocatalyst in highly enantioselective manner, where enantiomeric excesses of desired product of (I) or (II) are greater than 90%. Ar1 : aryl; and R : CH 3, CH 2OH. [Image].