Conditioning Chamber for Conditioning of Tissue Constructs

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a specialized conditioning chamber designed for the mechanical stimulation and conditioning of tissue constructs, including hard tissues like artificial bone. The chamber features uniquely engineered walls with sections to transfer and apply controlled pressure forces to cellular scaffolds, while maintaining sterile and isolated conditions. It uses sensors for monitoring biological and mechanical parameters and allows for the controlled supply and removal of growth media.

Use CasesContent extracted from patent full text and abstract with AI.

• Cultivation and maturation of engineered bone or cartilage for transplantation in regenerative medicine.
• In vitro mechanical conditioning of tissue constructs for research purposes, particularly in tissue engineering and biomechanics.
• Drug testing on mechanically stimulated tissue in a controlled, sterile environment.
• Educational and industrial-scale bioreactor setups for growing custom tissue grafts or studying cell responses to mechanical stimuli.
• Quality control and standardization of tissue constructs for clinical applications.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables reliable and repeatable mechanical stimulation of tissue constructs, critical for developing hard tissues like bone.
• Supports sterile, contamination-free conditioning, improving safety for clinical and research uses.
• Incorporates real-time monitoring of bio-parameters (like oxygen, CO2, pH) and mechanical forces, allowing precise control and quality assurance.
• Flexible design supports both soft and hard tissue engineering, expanding potential applications.
• Can be manufactured cost-effectively and reused, reducing operational costs for labs and clinics.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a temperature-control chamber (10) for controlling the temperature of tissue constructs, having chamber walls (20) which enclose a chamber volume (30) for receiving a cellular structure (200). At least one of the chamber walls (20) has a force-transmission section (40), comprising a force-receiving surface (42) on the outer face (22) of said chamber wall (20) for receiving a pressure force (DK) from a pressure-force actuator (110) and a force-transfer surface (44) on the inner face (24) of said chamber wall (20) for transferring the received pressure force (DK) to a cellular structure (200) which can be received in the chamber volume (30). Additionally, the at least one chamber wall (20) has at least one deformation section (50) separately from the force-transmission section (40) for elastically deforming when the pressure force (DK) is acting on the force-transmission section (40).