Scd83 for Wound Healing, Hair Growth, and Skin and Hair Care

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes the use of a soluble form of the CD83 protein (sCD83) and related compositions for enhancing wound healing, stimulating hair growth, and improving skin and hair care. The invention demonstrates that systemic or topical administration of sCD83 accelerates the closure of cutaneous and intestinal wounds (including chronic wounds in elderly, diabetic, or immunosuppressed patients) and stimulates hair regrowth in several models. sCD83 can be formulated in a topical hydrogel or administered systemically, offering both therapeutic and cosmetic applications.

Use CasesContent extracted from patent full text and abstract with AI.

• Medical treatment of hard-to-heal skin wounds, such as those in diabetic, elderly, or immunosuppressed patients.
• Accelerating the healing process after surgery or injury, especially for patients on immunosuppressive medication.
• Enhancing recovery and wound closure in intestinal injuries, such as those seen in inflammatory bowel disease (IBD).
• Therapeutic and cosmetic stimulation of hair regrowth after hair loss from disease, medication (e.g., chemotherapy), or physical stress.
• Cosmetic applications to improve hair density, regrow eyelashes, and promote overall skin and hair health through topical care products.
• Supporting wound healing and graft acceptance in organ transplantation where immunosuppression impairs wound closure.

BenefitsContent extracted from patent full text and abstract with AI.

• Accelerates both skin and intestinal wound healing, leading to faster recovery and reduced risk of infection.
• Effective in patients with impaired wound healing such as the diabetic, elderly, or immunosuppressed.
• Can be administered both systemically and topically (e.g., in hydrogel), giving flexibility of application.
• Stimulates robust hair regrowth, including eyebrows and eyelashes, with potential both for clinical and cosmetic benefit.
• Demonstrated action through immune system modulation, enhancing healing without adverse interference typical of immunosuppressive therapies.
• Topical application minimizes systemic exposure, reducing potential side effects and targeting treatment to local wounds or hair loss.
• Stable in formulation (such as hydrogels), supporting practical storage and use in healthcare or cosmetic products.
• Offers a new strategy for wound care and hair loss management beyond current drugs, some of which have significant drawbacks.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

Provided herein is the use of a soluble form of a member of the CD83 family of proteins (sCD83) for wound healing, including hard-to-heal wounds of elderly-, diabetic-, or patients under immunosuppressant medication. Further provided is the therapeutic use of the sCD83 for the systemic promotion of hair growth, after physical stress/medication, disease and/or depilation by application of systemic sCD83, and cosmetic methods for skin and hair care comprising the topical application of sCD83.