Pharmaceutical magnetic nano-particle composition

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention is a pharmaceutical composition containing magnetic nanoparticles coated with fatty acids (such as lauric acid), which can carry therapeutic drugs or imaging agents. These nanoparticles can be guided and accumulated in specific target tissues, like tumors, in the body using an external magnetic field. This enables precise delivery of drugs (for example, chemotherapeutics) or imaging agents directly to disease sites, improving treatment effectiveness and minimizing side effects. The composition is stable, can be sterilized, and is suitable for preparation with a range of agents for both therapeutic and diagnostic purposes.

Use CasesContent extracted from patent full text and abstract with AI.

• Targeted delivery of chemotherapy drugs to tumors in cancer treatment, minimizing exposure to healthy tissues.
• Delivery of imaging agents (for MRI, PET, CT) to specific tissues for improved diagnostic imaging.
• Combining diagnostic imaging and therapy (theranostics), enabling real-time monitoring of drug delivery and efficacy.
• Treatment of regional or local diseases such as arteriosclerosis, rheumatoid arthritis, or localized infections with targeted drug delivery.
• Controlled, repeated, or single-dose delivery of drugs in hard-to-reach tissues using catheter technology and magnetic guidance.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables precise delivery of drugs or imaging agents to specific tissues using an external magnetic field, reducing systemic side effects.
• Can be prepared and sterilized (autoclavable) under clinical conditions, ensuring safety and stability.
• Versatile: suitable for carrying both therapeutic agents and imaging agents, or a combination, for multiple applications.
• Fatty acid coating ensures high stability, efficient loading, and strong attachment of drugs to nanoparticles, with better control compared to other coatings.
• Reduces required dosage of toxic drugs (like chemotherapeutics) by increasing local concentration at the disease site, improving efficacy and decreasing overall toxicity.
• Non-polymer coating allows for easier and more flexible modification for different drugs or agents compared to traditional polymer-based systems.
• On-line monitoring and imaging enable personalized dosing and real-time assessment of drug delivery success.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a pharmaceutical composition comprising magnetic nano-particles for magnetic targeting of drugs and imaging agents. The invention further relates to the use of said pharmaceutical composition as a drug carrier, for use as an imaging agent, for use as a medicament and specifically for use in cancer treatment by magnetic drug targeting using an external magnetic field. The present invention also relates to a method for manufacturing said pharmaceutical composition and a method for guiding and accumulating said pharmaceutical composition to a target tissue contained in a subject.