Light Sheet Imaging Device, Scanner for a Light Sheet Imaging Device and Method of Operating a Light Sheet Imaging Device

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention describes a light sheet imaging device, such as a light sheet microscope, that generates a thin, extended sheet of light by moving a focused light beam through a sample. A key feature is that the optical component, which shapes the beam (for example, an axicon generating a Bessel beam), is moved together with the beam by a scanner so that the beam's orientation relative to the optical component is always constant. This approach improves the quality and extent of the light sheet, allowing for larger imaging areas and higher imaging fidelity.

Use CasesContent extracted from patent full text and abstract with AI.

• High-resolution 3D biological imaging, such as live-cell or tissue microscopy in biomedical research.
• Macroscopic imaging applications, for example visualizing fuel spray in engine chambers.
• Material science investigations where volumetric imaging is important.
• Industrial inspection systems requiring rapid and detailed scanning of large sample areas.
• Simultaneous multi-sample imaging in high-throughput research laboratories.

BenefitsContent extracted from patent full text and abstract with AI.

• Creates a light sheet with larger length and width, enabling imaging of bigger sample areas in a single scan.
• Maintains optimal beam quality across the entire illuminated region, leading to consistent image resolution and reduced optical artifacts.
• Enables fast volumetric imaging, improving temporal resolution for time-lapse studies.
• Supports advanced imaging modalities such as multiphoton excitation for deep-tissue imaging.
• Reduces the need for mechanically moving samples extensively, simplifying experimental setups and increasing throughput.

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Inventors & Applicants

Patent Abstract

A light sheet imaging device (2) is described, comprising a light source (4), for generating a light beam (6) to illuminate a sample (8), and a scanner (12), for moving the light beam (6) in such a way that a light sheet (14) is generated. The scanner (12) comprises an optical component (18), for shaping the light beam (6). Further, the scanner (12) is configured to move the optical component (18) together with the light beam (6) in such a way that an orientation of the light beam (6) relative to the optical component (18) remains unchanged during operation. In addition, a scanner (12) for a light sheet imaging device (2) is described as well as a method of operating a light sheet imaging device (2).