A Method for Determining the Presence of Chronic Rhinosinusitis with Nasal Polyps (crswnp) in a Patient

Simple SummaryContent extracted from patent full text and abstract with AI.

The invention provides a non-invasive method to diagnose chronic rhinosinusitis with nasal polyps (CRSwNP) by analyzing specific protein expression levels—especially the biomarker pappalysin-i (PAPPA)—in exosomes isolated from a patient's nasal mucus. The method can also monitor a patient's response to treatment for CRSwNP (such as corticosteroids) over time, and is implemented via specialized diagnostic kits. This detection relies on comparing protein markers in the patient’s mucus/exosomes with those from healthy controls, allowing for accurate disease identification and monitoring.

Use CasesContent extracted from patent full text and abstract with AI.

• Diagnosis of CRSwNP in patients with chronic nasal and sinus symptoms.
• Differentiating CRSwNP from other forms of rhinosinusitis or nasal conditions.
• Monitoring the progression or recurrence of CRSwNP after treatment or surgery.
• Assessing the effectiveness of anti-CRSwNP drugs, especially corticosteroids, in individual patients.
• Providing personalized treatment adjustments based on biomarker responses.
• Clinical research to study the pathophysiology and treatment responses in CRSwNP populations.

BenefitsContent extracted from patent full text and abstract with AI.

• Non-invasive sampling using nasal mucus instead of surgical tissue biopsies, reducing patient discomfort and risk.
• Enhanced diagnostic accuracy due to use of highly specific exosomal protein biosignatures, especially PAPPA.
• Ability to monitor disease activity and treatment response over time, supporting better disease management and prognosis.
• Applicable as a standardized kit, supporting reproducibility and ease of use in clinical laboratories and practices.
• May enable earlier intervention and personalized treatment plans by providing molecular-level disease insights.
• Potential to reduce overall healthcare costs by enabling more targeted therapies and avoiding unnecessary or ineffective treatments.

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Patent Abstract

The present invention relates to a method for determining the presence of chronic rhinosinusitis with nasal polyps (CRSwNP) in a patient. The present invention also relates to a method for determining whether or not a patient has chronic rhinosinusitis with nasal polyps (CRSwNP). Furthermore, the present invention relates to a method for monitoring and/or determining a response to treatment with an anti-CRSwNP drug and to kits for performing methods in accordance with the present invention.