Method for Light-Induced Release of an Amine from a Protected Amine Compound, Method for Preparing a Protected Amine Compound, Protecting Group and Compound

Technology Readiness Level

Simple SummaryContent extracted with AI.

This invention describes a method for releasing an amine compound from a chemically protected form using light (photoinduction). A specific protective group is attached to an amine to temporarily block its reactivity, and exposure to light triggers the removal of that protective group, freeing the active amine. The patent also covers the process for making these protected amine compounds and the protective group itself. This approach gives chemists precise, on-demand control over when and where an amine becomes chemically active.

Use CasesContent extracted with AI.

• Photocaged drug delivery systems where an amine-containing therapeutic is kept inactive until light is applied to a specific tissue or tumor site.
• Light-controlled synthesis in organic chemistry laboratories, enabling spatially and temporally precise deprotection steps in multi-step synthesis workflows.
• Photolithographic patterning in materials science, where amine release is triggered in defined regions to create functional surface patterns or microstructures.
• Development of photoactivatable dyes and pigments (consistent with C09B classifications) that change properties upon light-induced amine release.
• Synthesis of biologically active nucleoside or purine derivatives (consistent with C07D 473/34) with controlled activation for biochemical research.
• Light-triggered release of amine-based catalysts in photochemical reaction systems for controlled initiation of catalytic processes.

BenefitsContent extracted with AI.

• Provides precise spatiotemporal control over amine release, enabling activation only at a desired location and time using a light stimulus.
• Eliminates the need for chemical reagents or harsh conditions to remove the protecting group, reducing side reactions and byproduct formation.
• Enables non-invasive, remote triggering of amine deprotection, which is particularly valuable in biological and medical contexts where chemical additives are undesirable.
• Expands the toolkit of photoremovable protecting groups available for amine functionalities, which are historically more challenging to protect photolytically than other functional groups.
• Supports the development of light-responsive materials and dyes with tunable activation profiles for advanced materials applications.

Additional Information

Case Number HU: HU 2025/03

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a method for releasing an amine from a protected amine compound, a method for preparing a protected amine compound, the use of a protecting group for protecting an amine, and a compound.