Compounds for use in the treatment of filariasis

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes specific chemical compounds (including corallopyronin A and related derivatives) for treating or preventing filariasis, a parasitic disease caused by nematode worms. These compounds function by targeting and eliminating Wolbachia, essential symbiotic bacteria within the nematodes, ultimately killing the worms or stopping their development. The patent also claims pharmaceutical compositions and treatment methods using these compounds.

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of lymphatic filariasis in humans, which can cause elephantiasis and other diseases.
• Treatment of onchocerciasis (river blindness) in humans.
• Prevention of filariasis in at-risk populations through prophylactic use.
• Mass drug administration programs aimed at eliminating filarial diseases in endemic regions.
• Treatment of dirofilariasis (heartworm disease) in dogs and other animals.
• Application in situations where current drugs (like ivermectin or diethylcarbamazine) are ineffective, contraindicated, or resistance is emerging.

BenefitsContent extracted from patent full text and abstract with AI.

• Effectively eliminates both the Wolbachia bacteria and the filarial worms, attacking the disease at its root.
• No observed toxicity to mammalian (eukaryotic) cells in tested concentrations, indicating safety in humans and animals.
• Does not affect important commensal or unrelated pathogenic bacteria (narrow spectrum), reducing risk of side effects and resistance issues for other diseases, like tuberculosis.
• Potential for use in widespread public health programs due to low toxicity and efficacy via oral administration, facilitating mass treatment.
• Works against filarial worms that may be resistant or non-responsive to current anti-filarial treatments.
• Reduces the duration and intensity of treatment needed by efficiently depleting Wolbachia, potentially shortening the time to break disease transmission cycles.
• Can be synthesized chemically or produced biotechnologically, offering flexibility in manufacturing.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to compounds according to the general formula (1) for use in the therapeutic or prophylactic treatment of filariasis, a nematicidal composition comprising as an active ingredient a compound according to the general formula (1), and a method for treating filariasis.