Peripheral Zone Tumor Cells, Methods for Their Preparation and Use

Simple SummaryContent extracted from patent full text and abstract with AI.

This invention provides a method for isolating and characterizing tumor cells specifically from the peripheral zone (infiltrating margin) of a tumor, rather than the tumor's center. The method uses expression profiles of cell surface markers (such as CD133, CD87, VEGFR-2, and PDGFR-B) to distinguish and enrich for these peripheral zone tumor cells. These cells are important because they are more likely to remain after surgical tumor removal and are implicated in recurrence and metastasis. The invention also describes methods to use these cells for the discovery of new cancer diagnostics, targeted therapies, and potential vaccines.

Use CasesContent extracted from patent full text and abstract with AI.

• Developing new diagnostic tests to detect aggressive, infiltrative cancer cells remaining after tumor removal surgery.
• Screening and developing novel drugs that specifically target residual or peripheral zone tumor cells responsible for cancer recurrence.
• Studying the biology and molecular markers of infiltrative tumor cells to understand mechanisms underlying cancer spread or resistance to standard therapies.
• Generating cell-based cancer vaccines or dendritic cell vaccines using the purified tumor cells from the periphery.
• Providing reliable control samples for research, diagnosis, or prognosis of infiltrative cancers, including brain tumors such as glioblastoma.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables isolation and study of the specific tumor cells most responsible for cancer recurrence and metastasis, potentially leading to more effective therapies.
• Provides a standardized procedure to enrich for peripheral zone (infiltrative) tumor cells using molecular markers, increasing precision in research and clinical applications.
• Facilitates the identification of diagnostic molecular markers unique to infiltrative or metastatic tumor cells, which can improve early detection and monitoring of cancer.
• Supports the development of therapies that can target residual cancer cells post-surgery, reducing the risk of relapse and improving patient outcomes.
• May allow the design of more effective, customized immunotherapies and cell-based vaccines based on the specific properties of infiltrative tumor cells.

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Patent Abstract

The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.