Composition Comprising Beta-2-Adrenergic Receptor Agonist for Transdermal Administration

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This patent describes a transdermal (through-the-skin) composition containing beta-2-adrenergic receptor agonists—such as formoterol, salbutamol, salmeterol, fenoterol, or clenbuterol—together with solvents like dimethyl sulfoxide (DMSO), monoalcohols, water, or other penetration enhancers. The invention enables effective delivery of these compounds through the skin, targeting subcutaneous fat tissue to promote local fat reduction (lipolysis) without requiring oral or injected administration. The compositions can be formulated as gels, creams, sprays, or plasters, and are intended for both medical and cosmetic applications, especially for treating obesity, lipedema, or for body contouring.

Use CasesContent extracted from patent full text and abstract with AI.

• Topical treatment for local reduction of subcutaneous fat deposits in overweight, obese, or lipedema patients.
• Cosmetic procedures for body contouring and reducing localized fat without invasive surgery or injections.
• Development of transdermal patches or gels for personalized fat loss therapy.
• Adjunct therapy for patients with metabolic disorders requiring local fat reduction.
• Non-invasive alternative to traditional lipolysis (fat loss) treatments.

BenefitsContent extracted from patent full text and abstract with AI.

• Minimizes systemic side effects compared to oral or injected beta-2 agonists by localizing the effect to targeted fat regions.
• Non-invasive and user-friendly topical application eliminates the need for injections or surgery.
• Effective delivery through skin using DMSO or solvent blends overcomes traditional penetration challenges with such drugs.
• Potential for both therapeutic (medical) and cosmetic uses broadens commercial and healthcare applicability.
• Flexible formulation options (gels, sprays, creams, plasters) improve patient adherence and convenience.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a composition for transdermal administration, the composition comprising a compound selected from the group comprising formoterol, salbutamol, salmeterol, fenoterol, a mixture thereof, or a salt thereof, and dimethyl sulfoxide. The invention further relates to a composition comprising a compound selected from the group comprising salbutamol, clenbuterol, or a salt thereof, and comprises at least one of a monoalcohol or water.