Method of Diagnosing Asthma Subtypes

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a method and accompanying kit for diagnosing specific subtypes of asthma in patients by measuring and analyzing the expression levels of selected genes in a biological sample (such as blood). The method uses a panel of gene markers and software to create a gene expression profile, which is then compared to reference profiles to classify the patient's asthma subtype. This enables more personalized asthma treatment, as the subtype can guide the optimal choice of therapy.

Use CasesContent extracted from patent full text and abstract with AI.

• Clinical diagnosis of asthma subtypes to enable precise and individualized medicine.
• Selecting tailored antibody therapies (e.g., anti-IgE, anti-IL-5) for severe and difficult-to-treat asthma patients.
• Monitoring the effectiveness of asthma therapy by tracking changes in gene expression profiles over time.
• Integration into routine clinical laboratory testing for asthma endotyping using standard laboratory equipment (such as PCR).
• Research applications to study the molecular mechanisms and heterogeneity of asthma.

BenefitsContent extracted from patent full text and abstract with AI.

• Enables personalized or precision treatment of asthma, improving patient outcomes by targeting therapies according to subtype.
• Reduces ineffective treatments and minimizes unnecessary side effects by matching patients to the most appropriate therapy.
• Cost-effective and compatible with standard laboratory technologies, allowing widespread adoption in clinical settings.
• Simplifies the process; samples can often be obtained and tested without the need for specialized centers or expensive equipment.
• Allows for dynamic assessment and monitoring of disease progression and treatment efficacy, supporting adaptive management.
• Improves the allocation of healthcare resources and can lead to better economic outcomes for health systems by improving therapy efficiency.

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Patent Abstract

The present invention relates to methods of diagnosing an asthma subtype in a patient using a combinatory asthma endotyping assay. Furthermore, the invention relates to a kit and a marker panel for use in these method.