A Method for Using Xin Protein to Assess the Degree of Muscle Damage

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a method and kit for determining the degree of skeletal muscle damage in mammals by measuring the expression level of the Xin protein in biological samples such as muscle tissue, blood, or serum. The method uses specific standards of Xin protein expression to assess the severity of muscle damage, providing a more sensitive and reliable diagnostic tool than traditional markers. The kit includes a ligand (like an antibody) for detecting Xin and reference standards for evaluation.

Use CasesContent extracted from patent full text and abstract with AI.

• Diagnosing and monitoring the severity of muscular dystrophies and other myopathies
• Assessing muscle injuries in athletes and individuals with trauma or overuse injuries
• Monitoring the progression or recovery from cardiac muscle damage, such as following a heart attack
• Evaluating muscle regeneration and repair following therapeutic interventions or surgeries
• Supporting research on muscle disease mechanisms or drug efficacy by quantifying muscle injury and regeneration in preclinical and clinical studies
• Guiding personalized treatment plans by reliably grading the extent of muscle damage

BenefitsContent extracted from patent full text and abstract with AI.

• Xin protein expression is negligible in healthy muscle, allowing for sensitive detection of even minor muscle damage
• Provides quantitative information on the degree of muscle damage, not just presence or absence
• Applicable to a wide range of muscle injury causes (genetic, metabolic, traumatic, or exercise-induced)
• Potentially enables less invasive testing via blood samples as opposed to requiring tissue biopsies in some cases
• May outperform traditional muscle damage markers like creatine kinase in specificity and reliability
• Useful in both clinical and research settings for monitoring disease progression or response to treatment

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Inventors & Applicants

Patent Abstract

A method for determining the degree of skeletal muscle damage in a mammal is provided. The method comprises the steps of: determining the expression level of Xin protein in a biological sample from the mammal, comparing the Xin expression level in the sample to Xin expression level standards associated with degree of muscle damage and determining the degree of muscle damage in the sample based on the Xin expression level standards. A kit is also provided.