Solid and Liquisolid Formulations of Corallopyronin A

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes new solid and liquisolid pharmaceutical formulations containing corallopyronin A, an antibacterial compound. Because corallopyronin A is poorly soluble and difficult to use in its raw form, the invention embeds it in water-soluble polymers or loads it onto porous silica. This creates stable, easily handled powders or dosage forms (like tablets and capsules) that improve solubility and make oral administration possible and effective.

Use CasesContent extracted from patent full text and abstract with AI.

• Oral delivery of corallopyronin A for treating bacterial infections.
• Development of tablet or capsule forms of corallopyronin A for human or animal health.
• Use in clinical research and drug development to test corallopyronin A’s efficacy for diseases such as filariasis.
• Production of stable pharmaceutical products for easier transportation, storage, and administration.
• Potential use as an antibiotic therapy in cases where resistance is an issue, leveraging corallopyronin A’s unique antibacterial properties.

BenefitsContent extracted from patent full text and abstract with AI.

• Significantly improves the oral bioavailability of corallopyronin A, which is otherwise poorly soluble.
• Enables stable, solid dosage forms (tablets, capsules, etc.) from a sticky, oily compound.
• Simplifies manufacturing using conventional pharmaceutical processes and equipment.
• Enhances storage stability compared to pure corallopyronin A, extending shelf life under varying conditions.
• Facilitates dosing accuracy, patient compliance, and broader use in therapeutic applications.
• Lowers manufacturing costs and complexity compared to alternative methods for enhancing drug bioavailability.
• Supports industrial scale-up and regulatory approval by providing reproducible, stable drug forms.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to a solid or liquisolid formulation comprising corallopyronin A, wherein the formulation comprises an amorphous solid dispersion of corallopyronin A embedded in a water-soluble polymer or corallopyronin A loaded onto porous silica.