Method for isolating stem cells from a pad-like tissue of teeth

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This invention provides a new method to isolate non-embryonic (adult) stem cells from a unique, pad-like soft tissue found near the developing root of immature or wisdom teeth. The method involves surgically extracting teeth at a specific developmental stage and then separating and processing this special tissue to collect multipotent stem cells. These stem cells hold high regenerative potential and are easier to obtain in larger amounts compared to previous sources.

Use CasesContent extracted from patent full text and abstract with AI.

• Regenerative dental therapies, such as regenerating damaged dental or craniofacial tissue.
• Bone tissue engineering for repairing or replacing cranial or skeletal bone.
• Cell-based therapies for neurological disorders by differentiating the stem cells into neurons or nerve tissue.
• General regenerative medicine applications for repairing ectomesenchymal tissues (e.g., cartilage, ligament, connective tissue).
• Gene therapy applications by transfecting stem cells with therapeutic genes before transplantation.
• Research into neural crest-derived cell lineages and their developmental biology.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides a non-embryonic, ethically acceptable source of multipotent stem cells, avoiding ethical issues related to embryonic stem cells.
• Enables easier and more abundant harvesting of stem cells as the pad-like tissue is typically discarded during routine dental procedures.
• The cells obtained have broad differentiation potential, capable of becoming various cell types (bone, neural, connective tissue, etc.).
• Uses standard surgical and laboratory techniques, making the process accessible and scalable.
• Potential for personalized medicine, as cells can be sourced from the same individual who will receive the treatment, reducing rejection risk.
• Stem cells can be genetically engineered to enhance therapeutic outcomes or to track/monitor transplanted cells.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The invention relates to a method for isolating non-embryonic stem cells from a tissue that is located in immediate vicinity of immature, developing teeth or wisdom teeth. The invention further relates to non-embryonic stem cells derived from said tissue. The method according to the invention utilises a living soft tissue residing underneath the dental papilla 12 in immediate vicinity of the apical side of a developing tooth, which is clearly distinguished from other tooth tissue, such as dental papilla 12 or follicle. The pad-like tissue 16 can only be detected in a defined, specific developmental stage in an early phase of root formation. That is, identifying and separating the pad-like tissue 16 is only possible from the appearance of the bony alveolar fundus to the end of the formation of the root of the tooth.