Compositions and Methods for Altering Second Messenger Signaling

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes novel compositions and methods relating to second messenger signaling, specifically focusing on isomers of cyclic GMP-AMP (cGAMP) and the structure of the enzyme cyclic GMP-AMP synthase (cGAS). The invention provides new cGAMP analogs, variants, mimetics, and the structural data of cGAS, enabling the design and use of modulators—such as agonists or antagonists—of this enzyme. These compounds and structural insights allow for the modulation of immune signaling pathways relevant to interferon production in response to cytoplasmic DNA.

Use CasesContent extracted from patent full text and abstract with AI.

• Development of new drugs to modulate immune responses, especially in autoimmune or inflammatory diseases (e.g., systemic lupus erythematosus, Sjogren’s syndrome).
• Design and synthesis of research tools or kits for studying second messenger signaling and innate immune responses in biological research.
• Therapeutic intervention in disorders caused by overactive or dysregulated interferon pathways, such as suppressing inappropriate immune activation.
• Development of diagnostic assays or reagents for profiling immune function, interferon induction, or identifying dysregulation in cGAS-STING signaling.
• Application in vaccine adjuvant design to enhance immune responses during vaccination.
• Creation of computers systems and methods that use cGAS crystal structure data for computational drug screening or molecular docking studies.

BenefitsContent extracted from patent full text and abstract with AI.

• Provides molecular tools (analogs, mimics, variants) for precise control or modulation of the cGAS-dependent immune pathway.
• Enables targeted therapeutic approaches for diseases where cGAS or STING pathway dysregulation plays a key role, improving patient outcomes and reducing side effects compared to broad immunosuppression.
• Allows rational design of modulators based on detailed cGAS structural data, accelerating the development of highly specific drugs and inhibitors.
• Facilitates research into innate immunity, second messenger signaling, and cellular responses to cytoplasmic DNA, offering new insights and enabling novel diagnostics and treatments.
• Supports high-throughput drug discovery and computational modeling using structural data, optimizing lead identification.
• Increases stability and specificity of therapeutic candidates due to controllable chemical modifications identified through structural studies.

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Patent Abstract

The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.