Cyclohexane Compounds and Their Use as Antibiotics

Simple SummaryContent extracted from patent full text and abstract with AI.

This patent describes a new class of cyclohexane-based compounds that act as antibiotics by targeting a specific bacterial RNA element called the glmS riboswitch. Unlike existing antibiotics, these compounds disrupt bacterial gene regulation essential for cell wall biosynthesis by activating the riboswitch, ultimately inhibiting bacterial growth. The invention includes the compounds themselves, methods for their manufacture, pharmaceutical compositions, and their use in treating bacterial infections—particularly infections by drug-resistant strains like MRSA (methicillin-resistant Staphylococcus aureus).

Use CasesContent extracted from patent full text and abstract with AI.

• Treatment of infections caused by drug-resistant bacteria, notably MRSA and vancomycin-resistant Staphylococcus aureus (VRSA).
• Development of new antibiotics for hospital-acquired infections where traditional antibiotics have failed.
• Combination therapy with existing antibiotics (e.g., vancomycin) to enhance antibacterial efficacy and combat resistance.
• Formulation of oral, topical, or injectable antibiotics for human or veterinary use.
• Prophylactic (preventive) treatment in clinical settings to prevent bacterial outbreaks.

BenefitsContent extracted from patent full text and abstract with AI.

• Addresses urgent need for new antibiotics due to rising resistance against existing drugs.
• Novel mode of action by targeting the glmS riboswitch, reducing risk of cross-resistance with current antibiotic classes.
• Proven effectiveness in vitro against highly resistant bacteria such as MRSA.
• Potential for synergy with existing antibiotics to improve treatment outcomes and possibly lower required doses.
• Versatile for use in multiple pharmaceutical formulations (oral, topical, parenteral).
• May be used preventively in high-risk environments such as hospitals.

Technical Classifications (CPCs)

Inventors & Applicants

Patent Abstract

The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.